Primary pulmonary intravascular large B-cell lymphoma: A report of three cases and literature review
نویسندگان
چکیده
The present study aimed to investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung. The clinical and histopathological data of three patients, and the literature was reviewed. The Ethics Committees of Drum Tower Hospital approved the current study based on the three cases. Fever and respiratory symptoms were the main presenting symptoms. Serum lactate dehydrogenase and C-reactive protein were significantly increased. Diffuse ground glass opacities or nodular consolidations were seen on high resolution computed tomography. Lung biopsy revealed lymphoma cells in the lumen of small blood vessels. Tumor cells expressed cluster of differentiation 20 and melanoma associated antigen (mutated) 1. Primary pulmonary IVLBCL is extremely rare and its prognosis is poor. Full recognition of its clinical character and improvement of the diagnostic awareness may help to reduce missed diagnosis, and facilitate appropriate treatment.
منابع مشابه
Primary cutaneous large B cell lymphoma, leg type: A case report and review of the literature
Primary cutaneous large B-cell lymphoma leg type is a rare andaggressive neoplasm as defined by the recently updated WorldHealth Organization - European Organization for Research andTreatment of Cancer. We report a case of an 80-year-old manwith multiple cutaneous lesions. Here, we review the availableliterature and summarize clinical features and management ofthis type of cutaneous B-cell lymp...
متن کاملIntravascular Large B-cell Lymphoma: A Report of Two Cases
One of the rare variants of extranodal large B-cell lymphoma is intravascular large B-cell lymphoma (IVLBCL). Characteristics of IVLBCL include intraluminal selective proliferation of atypical lymphoid cells in small to medium-sized vessels. The etiologic of IVLBCL is unknown, but due to the growth pattern of this tumor, it is speculated that IVLBCL is caused by a defect in homing receptor of t...
متن کاملEarly detection of intravascular large B-cell lymphoma by 18FDG-PET/CT with diffuse FDG uptake in the lung without respiratory symptoms or chest CT abnormalities
Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of systemic extranodal non-Hodgkin diffuse large B-cell lymphoma (DLBCL). We report a rare case of IVLBCL who showed diffuse 18F-fluorodeoxyglucose (FDG) uptake in the lung in FDG-positron emission tomography/computed tomography (PET/CT) without respiratory symptoms or chest CT abnormalities. Serum biochemical studies...
متن کاملMALIGNANT LYMPHOMA OF THE UTERUS: REPORT OF A CASE AND LITERATURE REVIEW
Uterine lymphoma is a rare disease therefore, information regarding histologic type, immunophenotype of tumor cells and etiologic factors are limited. although secondary involvement of the genital tract occurs in up to 40% of cases• of disseminated lymphoma, lymphoma presenting with primary female genital tract . symptomatology is very unusual. We report a case of B-cell lymphoma in the ut...
متن کاملMultifocal Primary Non- Hodgkin’s Lymphoma of the Oral Cavity: Report of Three Cases and Review of the Literature
Objective: Oral non- Hodgkin’s lymphoma (NHL) is a relatively rare neoplasm that may develop in the soft tissues or jaw bones, with or without node or marrow involvement. Oral lymphomas are often difficult to diagnose as there are no characteristic clinical features and usually appear as non-tender swellings. Case: We describe clinical, radiographic, histopathological and immunohistochemica...
متن کاملPRIMARY PANCREATIC LYMPHOMA: A CASE REPORT AND LITERATURE REVIEW
Primary pancreatic lymphoma is a rare extranodal manifestation of any histopathologic subtype of B cell non-Hodgkin's lymphoma that predominantly involves the pancreas. It comprises less than 0.2% of pancreatic malignancies and less than 0.7% of non-Hodgkin's lymphomas. This lymphoma is almost never suspected clinically. It is usually diagnosed by surgical exploration for suspected adenoca...
متن کامل